The answer to the question is no. A beaker does not measure the voltage in the wire as it has no specified reference to measure against. There is a voltage across the terminals when they are open and this would be the working voltage (perhaps higher with unexpected over voltages) and it would have a voltage referenced to the chassis or other adjacent conductors (of relevance for the insulation withstand) though these are not used as a reference.
The voltage ratings on breakers are due to safe switching voltages without detrimental arcing and contact erosion AND insulation withstand capability.
The first rating is not important unless the breaker is open or operated (manually opened or closed or opened due to fault) as it relates to the contact gap (and speed of operation, gas or vacuum fill or quenching systems) and not to the closed circuit.
The second rating (less often even mentioned) is the insulation resistance and may be 500V on even low voltage breakers and exceeding this with respect to external surfaces, adjacent poles or mounting hardware will result in unintended breakdown that could easily cause fires.
These ratings are different for DC, AC, HF and will be affected by relative humidity and atmospheric pressure unless the breaker is a fully sealed unit.
As mentioned in my comment:
As a design goal all your components and assemblies have to have a rating greater than the actual supplied voltage. So if your battery now has 48 (possibly more when fully charged) volts then you need to make sure all your breakers, controllers and motors are all able and designed to be able to cope with the higher voltage.