There are many free (e.g. AppCad from Agilent) microstrip impedance calculators on the web. I've tested now several, because the first two did show a huge difference in the calculated impedance for a CPW waveguide on silicon, with exactly the same parameters (dieletric constant, geometry etc). One 50 Ohm, while the next 68 Ohm. This will probably generate huge losses.
So how can I be sure, I've chosen the right geometry of my waveguide and get correct impedance match? Should I switch to commercial simulaion software like CST microwave studio or HFSS to get the results nearest to real-world physics in this waveguides?